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KMID : 1151920210030010004
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Chronobiology in Medicine
2021 Volume.3 No. 1 p.4 ~ p.7
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Prospective Role of N-Acetyl-5-Methoxytryptamine and 5-Hydroxytryptophan in β-Cell Health and Improved Insulin Sensitivity in Hyperglycemia
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Raghav Alok
Mishra Brijesh Kumar
Tomar Renu
Jeong Goo-Bo
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Abstract
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Melatonin and serotonin are considered to be the important neurotransmitter and prime hormones responsible for the body homeostasis. The melatonin exert its effect on insulin signaling through melatonin receptors (MT-1 and MT-2). Similarly, 5-hydroxytryptophan, also plays an important role in insulin secretion, β-cells function thereby contributing an important role in diabetes management. Several animals and clinical studies suggested that supplementation of N-acetyl-5-methoxytryptamine and 5-hydroxytryptophan improves the insulin release from the β-cells of the pancreas and can be used as prospective therapy in management of diabetes and its associated complications.
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KEYWORD
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Insulin, Hyperglycemia, N-acetyl-5-methoxytryptamine, 5-hydroxytryptophan
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